Researchers from University of Macau find that Omega-3 polyunsaturated fatty acids from fish may help to remove metabolites, including amyloid-beta peptides, one of the factors that lead to Alzheimer's.
The research was published in the FASEB Journal. It suggested that Omega-3 polyunsaturated fatty acids (PUFAs) found in fish oil could improve the functioning of glymphatic system, which provides the clearance of waste from the brain.
For this discovery, scientists initially used transgenic fat-1 mice, which express endogenous Omega-3 PUFAs in the brain, in order to examine the effect of Omega-3 PUFAs on clearance function of glymphatic system.
The fat-1 mice is more enriched with endogenous Omega-3 PUFAs when compared to the wild-type mice. Omega-3 PUFAs promote the clearance system of glymphatic system compared to the control mice without fish oil supplementation.
Omega-3 PUFAs help maintain the brain homeostasis, which may be helpful in a number of neurological diseases, such as Alzheimer's disease, traumatic brain injury, and sleep impairment.