The 30-share barometer declined 140.86 points, or 0.59 per cent, to 23,508.36, with metal, capital goods, PSU and oil and gas leading the fall.
The index had gained 457.25 points in the last two straight sessions on the back of a rebound in the global market following a surge in crude oil prices.
Also, the NSE Nifty was trading lower by 45.80 points, or 0.63 per cent, at 7,145.95.
Brokers said that apart from profit-booking in recent gainers, a weak trend at other Asian bourses tracking overnight losses in the US dampened sentiment.
Hong Kong’s Hang Seng was down 0.53 per cent and Japan’s Nikkei fell 2.23 per cent. Shanghai Composite fell 0.58 per cent in early trade.
The Dow Jones Industrial Average ended 0.25 per cent lower in yesterday’s trade.