Manchester United made eight changes to the side but they suffered a loss to Valencia in the UEFA Champions League and could face either Real Madrid or Barcelona in the next round.
Tottenham held Barcelona to a 1-1 draw but their qualification for the last 16 of the UEFA Champions League was assured only after PSV Eindhoven held Inter Milan to a draw.
Liverpool were boosted by a goal from Mohamed Salah and a late save from goalkeeper Alisson Becker to beat Napoli and boost them into the last 16 of the UEFA Champions League.
Borussia Dortmund's lead stretched to seven points after RB Leipzig scored a 2-0 win over Borussia Moenchengladbach while Bayern Munich slipped to fourth.
The Superclasico encounter between River Plate and Boca Juniors is not the most violent rivalry in football. Here is a list of other famous and 'deadly' rivalries in the sport.
River Plate have refused to play the already twice-postponed Copa Libertadores final against Boca Juniors in Madrid, stating that it was 'incomprehensible'.
Manchester City handed their manager Pep Guardiola his 400th win as manager as they moved five points clear at the top of the Premier League while Manchester United's woes continued
Cristiano Ronaldo continued his red-hot streak in the Serie A as he converted a penalty against Fiorentina to help Juventus extend their lead in the Serie A to 11 points.
